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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTPN6 All Species: 16.97
Human Site: S151 Identified Species: 33.94
UniProt: P29350 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P29350 NP_002822.2 595 67561 S151 D F V L S V L S D Q P K A G P
Chimpanzee Pan troglodytes XP_001163468 596 67703 D153 F V L S V L S D Q P K A G P G
Rhesus Macaque Macaca mulatta XP_001110915 597 67615 S153 D F V L S V L S D Q P K A G P
Dog Lupus familis XP_543844 595 67669 S151 D F V L S V L S D Q P K A G L
Cat Felis silvestris
Mouse Mus musculus P29351 595 67540 N151 D F V L S V L N D Q P K A G P
Rat Rattus norvegicus P81718 613 69560 N153 D F V L S V L N D Q P K A A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519010 556 61792 H129 P V G D Q V T H I R I Q N S G
Chicken Gallus gallus Q90687 593 67964 T153 D F V L S V R T G D D K G E S
Frog Xenopus laevis NP_001085766 594 68095 T153 D F V L S V L T S E E K L E N
Zebra Danio Brachydanio rerio NP_956254 589 66986 T151 D F V L S A L T D D Q T S S G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29349 845 92957 D153 F V L S V R T D D K V T H V M
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784121 533 60826 A105 L K Y P L N C A D P T N E R W
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.8 96.1 N.A. 94.4 91 N.A. 68 54.2 58.3 64.7 N.A. 33.8 N.A. N.A. 43.3
Protein Similarity: 100 98.8 98.4 97.9 N.A. 98.1 94.9 N.A. 72.9 70.7 72 78.4 N.A. 46.9 N.A. N.A. 60.8
P-Site Identity: 100 0 100 93.3 N.A. 93.3 86.6 N.A. 6.6 46.6 53.3 46.6 N.A. 6.6 N.A. N.A. 6.6
P-Site Similarity: 100 13.3 100 93.3 N.A. 100 93.3 N.A. 20 53.3 66.6 60 N.A. 20 N.A. N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 9 0 9 0 0 0 9 42 9 0 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 67 0 0 9 0 0 0 17 67 17 9 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 9 9 0 9 17 0 % E
% Phe: 17 67 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 0 0 0 0 0 9 0 0 0 17 34 25 % G
% His: 0 0 0 0 0 0 0 9 0 0 0 0 9 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 9 0 9 0 0 0 0 % I
% Lys: 0 9 0 0 0 0 0 0 0 9 9 59 0 0 0 % K
% Leu: 9 0 17 67 9 9 59 0 0 0 0 0 9 0 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 0 0 9 0 17 0 0 0 9 9 0 9 % N
% Pro: 9 0 0 9 0 0 0 0 0 17 42 0 0 9 34 % P
% Gln: 0 0 0 0 9 0 0 0 9 42 9 9 0 0 0 % Q
% Arg: 0 0 0 0 0 9 9 0 0 9 0 0 0 9 0 % R
% Ser: 0 0 0 17 67 0 9 25 9 0 0 0 9 17 9 % S
% Thr: 0 0 0 0 0 0 17 25 0 0 9 17 0 0 0 % T
% Val: 0 25 67 0 17 67 0 0 0 0 9 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % W
% Tyr: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _